Abstract：Objective To explore the impact of human papillomavirus （HPV） vaccination status and different surgical methods on the prognosis of early-stage cervical cancer （ECC）.  Methods A total of 88 ECC patients treated at Baogang Hospital in Inner Mongolia were selected and divided into four groups based on their HPV vaccination status and surgical methods: Group A （n＝23）, Group B （n＝23）, Group C （n＝21）, and Group D （n＝21）. Surgical methods included loop electrosurgical excision procedure （LEEP） and cold knife conization （CKC）. Efficacy-related indicators were compared among the four groups. Results Significant differences were observed among the four groups in terms of surgical duration and intraoperative blood loss （F＝144.390, 95.960; both P＜0.05）. Complication rates also varied significantly among the groups （χ2＝15.590, P＜0.05）. Six months postoperatively, squamous cell carcinoma antigen（SCC-Ag） levels in four groups were lower than preoperative levels, with the most significant reduction observed in Group C （F＝34.470, P＜0.05）. At one year postoperatively, the recurrence and HPV infection rates differed significantly among the four groups （χ2＝18.411, 15.588; both P＜0.05）, with Groups C and D showing lower rates. Conclusion Compared to CKC, LEEP offers shorter surgical duration, less intraoperative blood loss, and lower complication rates. Patients receiving combined HPV vaccination and surgical treatment demonstrated significantly reduced postoperative SCC-Ag levels, recurrence rates, and infection risks.