Abstract：Objective To explore the effects of She medicine Zhuyu Wendan decoction  on inflammatory factors and vascular endothelial function in patients with stable angina pectoris of phlegm-stasis interconnections.  Methods A total of 70 patients with stable angina pectoris with phlegm stasis interconnection, were treated in the Department of Cardiovascular Medicine of Lishui Traditional Chinese Medicine Hospital from July 2023 to July 2024 were screened and enrolled, who were randomly divided into the observation group and the control group, with 35 cases in each group. The control group received conventional therapy including enteric-coated aspirin tablets, atorvastatin calcium tablets, and nitroglycerin tablets. The observation group received She mediane Zhuyu Wendan decoction in addition to the treatment given to the control group. After 10 weeks of treatment, the clinical efficacy, Chinese medicine syndrome scores, Seattle angina questionnaire （SAQ）scores, inflammatory cytokine levels, and vascular endothelial function indicators were compared between the two groups. Results After 10 weeks of treatment, the total efficiency in the observation group was significantly higher than that in the control group（χ2＝69.00，P＜0.05）. Both groups showed decreased TCM syndrome scores and elevated SAQ scores. The serum levels of interleukin-1β （IL-1β）, tumor necrosis factor-α （TNF-α） and C-reactive protein （CRP） and endothelin-l （ET-1） levels decreased, while nitric oxide （NO） and malonaldehyde （MDA） levels increased in both group, with the changes being more significant in the observation group （t＝8.12, 4.43, 4.47, 2.99, 7.17, 2.14, 2.42, 2.07, 4.73, 2.28, 4.19; all P＜0.05）. However, there was no statistically significant difference between the groups in the SAQ domain of disease perception （t＝0.06, P＞0.05）. No adverse reactions were observed in either group. Conclusion The effect of She medicine Zhuyu Wendan decoction demonstrates superior therapeutic efficacy compared to conventional in the treatment of stable angina pectoris. It significantly improves vascular endothelial function, reduces inflammatory responses and TCM syndrome scores, and has good safety.