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电子期刊 >> 正文 |
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基质金属蛋白酶及其组织抑制物与子宫内膜癌的浸润和转移的关系
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作者：董燕 |
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单位：大连市妇幼保健院 辽宁 大连 116033 |
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分类号：R737.33 |
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出版年,卷(期):页码：2005,22(6):0-0 |
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摘要：
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子宫内膜癌与其他肿瘤一样,其发生、浸润和转移是一个多步骤的复杂过程.首先必须降解细胞外基质(ECM)及基底膜(BM),这一降解过程主要依赖蛋白水解酶.基质金属蛋白酶(matrix metalloproteinases,MMPs)是一类重要的蛋白水解酶,能分解纤维类胶原[1],对ECM有广泛的降解作用.MMPs与基质金属蛋白酶组织抑制物(Tissue inhibitors of metalloproteinase,TIMPs)的相互作用是调节ECM动态平衡的重要因素,因此,也成为恶性肿瘤细胞浸润和转移的重要调节因素.在此对MMPs和TIMPs与子宫内膜癌的浸润和转移的关系作一综述.
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基金项目：
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作者简介：
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参考文献：
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