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电子期刊 >> 正文 |
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摘要：
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为了解胎儿在宫内发育状况,对先天性和遗传性疾病及时做出诊断,血清标志物的检测做为非侵入性产前诊断的方法受到越来越多的关注.自Seppala等在1967年首次报道甲胎蛋白(AFP)浓度与胎儿异常明显相关以来,相继发现与妊娠相关疾病的血清标志物有数十种,常用母体血清标志物有AFP、游离雌三醇(uE3)、绒毛膜促性腺激素(HCG)、妊娠相关血浆蛋白A(PAPP-A)、妊娠特异性β1糖蛋白(SP1)、抑制素-A等.
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参考文献：
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Saller DN.Canick JA Maternal serum screening for fetal Down′s syndrome:clinical aspects 1996 Jauniaux E.Brown.Snijders RJM Early prenatal diagnosis of triploidy 1997 Noble PL.Wallace EM.Snijders RJM Maternal seruminhibinA and free β - HCG concentrations in trisomy 21 pregnancies at 10 to 14 weeks of gestation 1997 Spencer K.Spencer CE.Power M One stop clinic for assessmentof risk for fetal anomalies: a report of the first year of prospective screening for chromosomal anomalies in the first trimester 2000 Tercanli S.Holzgreve W.Batukan C Screening for aneuploidy by first trimester nuchal ranslucency measurement; results from a prospective trial including 1980 cases in a single center in Switzerland 2002(1) Zimmermann R.Hucha A.Savoldelli G Serum parameters and nuchal translucency in first trimester screening for fetal chromosoma abnormalities 1996 Wald NJ.Hackshaw AK Combining ultra,nud and biochemistry in first trimester screening for Down's syndrome 1997(9) Wald NJ.George L.Smith D Serum screening for Down's syndrome between 8 and 14 weeks of pregnancy 1996(3)
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