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电子期刊 >> 正文 |
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摘要：
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白细胞介素2受体(IL-2R)主要由活化的T淋巴细胞释放,它由三个亚单位组成,即IL-2R-α、IL-2 R-β和IL-2 R-γ.可溶性白细胞介素2受体(sIL-2R)是来源于活化的T细胞膜上IL-2R α链的成分.它可与IL-2相互作用介导体内免疫反应.由于神经系统有其自身的免疫学特点,临床上将sIL-2R应用于神经系统疾病的病情分析、判断疗效及预后日渐增多.现就目前临床应用涉及较多的几个方面作如下综述.
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作者简介：
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参考文献：
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陈寿权.章锦湘.王明山 急性脑血管病血清肿瘤坏死因子α和可溶性白细胞介素-2受体α的研究 [期刊论文] -中国危重病急救医学1996(11) 秦淑存 细胞因子与动脉硬化 1994(5) 马金城.刘汇波 内皮素与脑血管病 1993(3) 王昆润 动脉硬化性心血管病患者的纤维蛋白溶解活性和白细胞介素活性 1993(6) 姚娟.王颖.于沁 中枢神经系统疾病患者脑脊液中的IL-2R 1998(2) Kittur SD.Kittur DS.Soncrant Soluble interlukin- 2 receptor in cerebrospinal fluid from individuals with various neurological disorders 1990 Aurelius E.Andersson B.Forsgren M Cytokines and other markers of intrathecal immune response in patients with herpes simplex encephalitis 1994(3) Sharief MK.Hentges R.Ciardi M Intrathecal immune response in patients with the post-polio syndrome 1991(11) Bygbjerg IC.Hansen MB.Ronn AM Decreased plasma levels of factor Ⅱ +Ⅶ +Ⅹ correlate with increased levels of soluble cytokine receptors in patients with malaria and meningococcal infections 1997(2) Rolfs A.Muhlschlegel F.Jansen - Rosseck R Clinical and immunologic follow- up study of patients with neurocysticercosis after treatment with praziquantel 1995(3) Miller CH.Quattrocchi KB.Frank EH Link out humoral and cellular immunity following severe head injury: review and current investigations 1991(2) Bansil S.Troiano R.Cook SD Clinical correlation with serumsoluble interleukin- 2 receptor levels in Guillain - Barre syndrome 1991(8) Bansil S.Mithen FA.Singhal BS Books elevated neopterin levels in Guillain - Barre syndrome. Further evidence of immune activation 1992(12) Hartung HP.Schafer G Suppression of P2 - t cell line - mediated experimental autoimmune neuritis by interleukin - 2 receptor targeted monoclonal antibody ART 18 1989 Shrief MK.Ingram DA.Swash M Circulating tumor necrosis factor- alfha correlates with electrodeiagnostic abnomalties in Guillain - Barre syndrome 1997(1) Melanie Ott.Demisch L.Enelhardt W Interleukin - 2 soluble interleukin - 2 receptor, neopterin, L - tryptophan and β -microglobin levels in CSF and serum of patients with relapsingremitting or chronic - progressive multiple sclerosis 1993(2) Ferrarini AM.Sivieri S.Bulian Time- course of interleukin - 2 receptor expression in interferon beta - treated multiple sclerosis patients 1998(2) Sivieri S.Ferrarini AM.Gollo P Multiple sclerosis: IL- 2 and sIL - 2R levels in cerebrospinal fluid and serum. Review of literature and critical analysis of ELISA pitfalls 1998(1) Wandinger KP.Wessel K.Nenstock P Diminished production of type - 1 interferons and interleukin - 2 patients with multiple sclerosis 1997(1) Freedman MS.Muth KL.Trotter JL Prospective serial analysis of interleukin - 2 and soluble interleukin - 2 receptor in relapsingremitting multiple sclerosis 1992(8) Bansil S.Mithen FA.Cook SD Serum soluble interleukin- 2 receptor levels in chronic progressive, stable and steroid- treated multiple sclerosis 1991(4) Deckert - schluter D.Schluter G.Schwendemann Evaluation of IL-2, sIL- 2R, IL- 6, TNF- α, andIL- 1 β levels in serum and CSF of patient with optic neuritis 1992(1) 李君武.韦静.赖祥青.李鸿智 癫痫患者血清可溶性白细胞介素2受体的检测 [期刊论文] -中国神经精神疾病杂志1996(2) 潘进钱.瞿宣兴.林向阳 脑胶质瘤患者脑脊液SIL--2R水平变化的研究 1997(5) 潘蔚然.惠国珍.徐庚达 肿瘤浸润淋巴细胞过继免疫治疗脑胶质瘤实验研究 1996(4) Yamaguchi T.Kira J.Koyanagi Y A simple method for the propagation and purification of gamma delta Tcells from the peripheral blood of glioblastoma patients using solid-phase antiCD3 antibody and soluble IL-2 1997(1) Hayashi M.Kida K.Yoshinaga Possible distinct pathogenesis in low responder myasthenia gravis: association of soluble interleukin - 2 receptor with acetylcholine receptor antibody titre or abnormal thymus 1996(2) 孙宏.国红.许贤豪.庞风疹.李宝林.王红.王秀云.叶霜.陈品 重症肌无力患者外周血乙酰胆碱受体特异性T细胞sIL-2R,IFN-γ,IL- … [期刊论文] -中华神经科杂志1998(2) Leblhuber F.Walli J.Tilz GP Systemic changes of the immune system in patients with Alzheimer′ s dementia 1998(25-26) Leblhuber F.Walli J.Demel U Increased serum neopterin concentrations in patients with Alzheimer′s disease 1999(4) Engelborghs S.De Brabander M.De Cree J Unchanged levels of interleukins neopterin, interferon - gamma and tumor necrosis factor- alqha in cerebrospinal fluid of patients with dementia of the Alzheimer type 1999(6) Yamasaki K.Kira J.Koyanagi Y Longterm, highdose interferon -alpha treatment in HTLV - 1 - associated myelopathy/tropic spastic paraparesis: a combined clinic, virologic and immunological study 1997(2) Bujia J.Kim C.Bruegel F Soluble interleukin 2 receptors in patients with Bell′s palsy 1996(3) Leblhuber F.Walli J.Tilz GP Linkout activated immune system in patients with Huntingtington′s disease 1998(10) Segal JL.Brunnamann SR Circulating levels of soluble interleukin - 2 receptors are evelated in the sera of humans with spinal cord injury 1992 Segal J L.Gonzales E.YousefS Circulating levels of IL - 2R,ICAM - 2,and IL - 6 in spinal cord injuries 1997(10)
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