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电子期刊 >> 正文 |
摘要:
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蛛网膜下腔出血后最常见的并发症是迟发性脑血管痉挛(简称DCVS),其发生率高达31.6%~66%[1].致死率和致残率较高,长期困扰着临床医生.现就其内科药物治疗综述如下. 1 甲基强的松龙 大量实验和临床研究表明,蛛网膜下腔出血后脑血管痉挛发生的原因之一是脑血管周围的免疫(炎症)反应,因为类固醇类抗炎药物(简称SAIDs)具有抗炎和免疫抑制双重作用,一般剂量主要抑制细胞免疫,大剂量也抑制体液免疫.
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候熙德 神经病学 1996 Yasukawa K.Kamijou Y.Manose G The experiences of large amount of steroid therapy for symptomatic vasospasm after subarachnoid hemorrhage: clinical analysis of 21 cases 1994(1) Juvela S Aspirn and delayed cerebral iscgemia after aneurysmal subarachnoid hemorrhage 1995(6) Toda N.Kawakami M.Yoshida K Constrictor action of oxyhemoglobin in monkey and dog basilar areties in vivo and in vitro 1991(3) Hirashima Y.Endo R Prevention of cerebrovasospasm foloowing subarachnoid hemorrhage in rabbits by the plateletactivating factor antagonist 1996 Hamders A.Kakariedka A.Braakman R Trumatic subarachnoid hemorrhage and its treatment with nimodipine 1996 Zuccarello M.Soattin GB.Lewis AI Prevention of subarachnoid hemorrhage induced cerebral vasospasm by oral administration of endotheliin receptor antagonists 1996 Luer M.Dujovny M.Slavin KV Loss og nitric oxide synthase immunoreactivity in cexebral casospass 1995 Macdonald RL.zhang J.Sima B Papavenine - sensitive vasospasm and asterial contractility and compliance after subarachnoid hemorrhage in dogs 1995 Kassell NF.Haley EC.Appersen - Hansen C Randomized doubleblind, vebicle- controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia and New Zealand 1996
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