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电子期刊 >> 正文 |
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摘要：
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目的:探讨长效β2-肾上腺素能受体激动剂formoterol(福莫特罗)在哮喘治疗中的抗炎途径.方法:28例轻、中度发作期哮喘患者被随机分为两组:formoterol治疗组14例,40μg每日2次,口服;procaterol(丙卡特罗)治疗组14例,50μg每日2次,口服,疗程4周.治疗前后ELISA法测定血清IL-8含量,同时测定肺通气功能.结果:哮喘患者血清IL-8含量显著升高与同时测定的肺通气功能结果呈显著负相关(P＜0.02).formoterol治疗组血清IL-8含量由治疗前的(342.60±135.69)pg/ml降至治疗后的(170.93±82.83)pg/ml,差异有显著性(P＜0.005);procaterol治疗组血清IL-8含量由治疗前的(293.90±116.20)pg/ml降至治疗后的(232.00±112.72)pg/ml,差异无显著性(P＞0.05).两组IL-8治疗前后的差值比较差异有显著性(P＜0.01).结论:formoterol治疗组IL-8下降更为明显,提示与formoterol抗炎作用有关.
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参考文献：
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Wong BJ.Dolorich J.Ramsdale EH Formoterol compared with beclomethasone and placebo on allergen - induced asthmatic responses 1992 Eda R.Sugiyama H.Hopp RJ Inhibitory effects of formoterol on PAF induced eosinophil chemotaxis and degranula - tion 1993(4) Subrammanian N Inhibition of immunological and nonimmunological histamine release from human basophils and lung mast cells by formoterol 1986(3) Rabe K.Dent G.Giembyc M Effects of long - acting agonist formoterol vs.salbutamol on LT B4 induced Ca2+ mobi - lisation,H2O2 and TXB2 release in guinea - pig eosinophils 1990 Erjefalt JS.Andersson P.Gustafsson B Allergen challengeinduced extravassation of plasma in mouse airways 1998(8) Sugiyama H.Okada C.Bewtra A The effect of formoterol on the late asthmatic phenomena in guinea pigs 1992 Whelan CJ.Johnson M.Vardev CJ Comparison of the antiinflammatory properties of formoterol, salbutamol and salme - terol in guinea - pig skin and lung 1993
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