Objective:To investigate the levels of VEGF,and SIL-2R(serum soluble interleukin-2 receptor)in serum in the primary liver cancer before and after transcatheter arterial-embolization(TACE).Methods:Fasting venous blood(3ml)were collected from 30 cases with clinical diagnosis of hepatocellular carcinoma in the morning,respectively on the 1st day before operation,the 1st,7th day and 1 month after interventional therapy.At low temperature,serum was separated and stored in -70℃,VEGF,SIL-2R was detected with ELISA.Results:Serum VEGF levels at the 1st day before the TACE,at the 1st day,7th day,and 1 month after the treatment was significantly increased at 1st after operation when compared with 1st before operation,There was statistically significant difference(P<0.05),it significantly decreased at 7th day compared with 1st before operation,and 1st after operation.,there was statistically significant difference (P<0.05),it significantly increased at 1 month compared with 7th day after operation,there was statistically significant difference (P<0.05),but there was no significant difference compared with 1st before operation(P>0.05).Serum SIL-2R levels at the 1st day before the TACE,at the 1st day,7th day,and 1 month after treatment compared with 1st before operation serum SIL-2R levels at 1st after operation was no significant difference(P>0.05),but serum SIL-2R levels significantly decreased at 7th compared with 1st before operation,and1st after operation.There was statistically significant difference(P<0.05),increased at 1 month compared with 7th day after operation (P<0.05),but significantly lower than 1st before operation(P<0.05).Conclusions:(1)serum VEGF,SIL-2R levels have a significant dynamic change following TACE treatment.(2)Dection of serum VEGF,SIL-2R could be used as effictive evaluation indicators of transcatheter arterial-embolization