Objective:To determine whether loop electrosurgical excision procedure(LEEP)can be instead of with colposcopic multiple biopsies and to evaluate the clinical value of LEEP in diagnosis and management of cervical intraepithelial neoplasia(CIN).Methods:62 patients with CIN diagnosed and treated were retrospectively analyzed focusing on the comparative study in pathology between LEEP and colposcopic multiple biopsies.Results:Of the 62 patients,there was a correlation in pathology between LEEP and colposcopic multiple biopsies in 41 cases,but there was not much correspondence between two methods in 21 cases.After LEEP,hysterectomy was performed in 7 cases because of early invasive carcinoma or intraepithelial carcinoma.55 cases were closely followed up in a period of 6 months.In the 6 months,no cytology abnormality was detected.Conclusions:LEEP had important values in diagnosis of CIN,and it could not be instead of colposcopic multiple biopsies.LEEP was also a good method in managing CIN.