Objective:Discussion treatment effect of Polygonum multiflorum compound preparation on the mouse model with aluminum exposure.Methods:A day with 16 g/L concentration(AICI3)mixed with aluminum chloride fed mice at the same time with 2 g/L of aluminum nitrate solution to the drinking water of mice.For 5 months(150 days)exposured experiments.Exposure to 100 days would be grouped mice:treatment 1,treatment 2 group,model group,a separate normal group(control group),a group with administration of polygonum multiflorum thunb oral treatment of compound preparation,rule 2 group traditional Chinese Medicine Haierfu row metal treatment as a treatment for oral gavage control group,model group and normal group administered with distilled water for volume control.100 days after treatment and exposure at the same time until the end of the experiment.Before the experiment,66,104,125,132,145 day for determination of water maze memory.The end of the experiment,blood from the eye,before separation of serum biochemical parameters,and then animals were killed with formaldehyde from the brain to deal with after the pathological examination(another report).Results:Treatment of 4 days (exposure 104 days) and swim before the time of arrival of each group had no significant difference,but when the treatment of 4 days normal error rate for 0,was significantly lower than other groups;25 d treatment,the treatment group and normal group 1,the arrival time and errors rate was significantly lower than the other two groups;the treatment of 32 d and 145 d model group arrived in time and error rate was significantly higher than other 3 groups.TG and urea between the groups there was no significant difference.Conclusions:Mice induced significant mental retardation,serum biochemical changes in varying degrees after treatment improved significantly.