Objective:To summarize the experiences in treatment of massive and deep burn patient with cardiopulmonary arrest in shock stage.Methods:A patient with 96% TBSA flame burn injury(deep second degree 4%;Ⅲ,Ⅳ degree 92%),complicated with moderate inhalation injury and cardiopulmonary arrest in shock stage.The primary treatment included optimal fluid resuscitation,early tracheotomy,cardiopulmonary resuscitation(CPR),early escharectomy,autologous micoroskin grafting and alloskin grafting.In addition,enteral nutrition support and reasonable antibiotics therapy were also adopted.Results:Immediate and successful CPR was performed when cardiopulmonary arrest occurred in massive and deep burn patient who was in shock stage.And then,after correct and effective preoperative preparation,tow times early escharectomy,autologous micoroskin grafting and alloskin grafting were performed.Because of the lack of autoskin donor site,11 times autoskin graft operations were undertaken when the autoskin donor was available.Finally the wounds healed completely after 128 days and the patient survived.Conclusions:For those patients with massive burns and cardiopulmonary arrest in shock stage,individualization fluid resuscitation,immediate and successful CPR was the basis of rescuing.And after CPR,choosing best time to operation,enhancing systemic supporting treatment in perioperative period,early escharectomy was feasible and essential to stabilize the patients' condition and reduce complications.Infection control,internal organ complication management and nutrition support were also essential.