Objective:To compare radial approach with femoral approach for coronary angiography(CAG)and percutaneous coronary intervention(PCI).Methods:670 cases undergoing CAG and /or PCI were divided into two groups,radial approach group(n=320)and femoral approach group(n=350).The procedure success rates and complication were compared and analyzed statistically.Results:The success rate of CAG was not different between two groups(96.9% vs 99.4%,P>0.05).The success rate of PCI was not different between two groups(91.8% vs 96.7%,P>0.05).But 6 patients undergoing PCI in the radial group crossed over to the femoral group.The incidence of local complication in the femoral group was significantly higher than that in the radial group(22.6% vs 1.9%,P<0.001).Conclusions:The radial approach indeed reduced the local complication in comparison with the standard transfemoral access,but the radial access was technically more challenging.