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电子期刊 >> 正文 |
| 不同化疗方案治疗晚期大肠癌的疗效观察 |
| 作者：盛妙华 |
| 单位：湖南湘潭钢铁公司职工医院 |
| 关键词：奥沙利铂 氟尿嘧啶 亚叶酸钙 大肠癌 联合化疗 |
| 分类号：R735.34 |
| 出版年,卷(期):页码：2010,27(1):22-23 |
| 摘要： |
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目的:研究奥沙利铂、氟尿嘧啶和亚叶酸钙(FOLFOX方案)联合治疗晚期大肠癌的疗效和毒性反应,并将该方案与氟尿嘧啶、亚叶酸钙(DeGramont方案)治疗方案相比较。方法:经病理确诊的晚期大肠癌62例分为两组,治疗组32例,予以FOLFOX方案治疗;对照组30例,予以DeGramont方案治疗。两组均治疗4个化疗周期以上。结果:治疗组有效率为46.9%,常见的毒性反应为神经毒性;对照组有效率为16.7%,与治疗组差别有统计学意义,未见神经毒性,其他毒性反应与治疗组无统计学差异。结论:奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗晚期大肠癌,患者对其耐受良好,毒副反应较轻,疗效高于氟尿嘧啶加亚叶酸钙方案。 |
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Objective:To study the efficacy and toxicity of oxaliplatin,5-Fu and CF for advanced colorectal carcinoma.Methods:62 colorecta carcinoma patients were randomized into FOLFOX4 group(n=32)and regimen(n=30).All patients received four course of chemotherapy.The treatments were both repeated every 2 weeks.Results:The overall reponse rate of the group with oxaliplatin was 46.9%(15/32).The main toxicity was neurotoxicity.And the overall response rate of the group without oxalip-latin was 16.7%(5/30).Conclusions:Our results indicated that combined oxaliplatin and 5-Fu with CF regimen was effective for advanced eolorectal cancer.And this regimens was superior to that without oxaliplatin. |
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