Objective:To make cancer patients comprehend knowledge related to chemotherapy,enhance their confidence of overcoming disease,and cooperate with the physician in completing chemotherapy successfully.Methods:40 medium-terminal cancer patients received health guidance,including psychological nursing,dietary guidance,repose guidance,complication prevention guidance,infection prevention guidance and discharge guidance.Their mental state,diet request,complication prevention knowledge and infection prevention knowledge before and after intervention were evaluated by questionnaires.Results:There was significant difference between the scores of the cancer patients before and after intervention(P<0.001).Conclusions:Effective health guidance elevated patients' confidence of overcoming disease,enhances their chemotherapy adaptability,prolonged their lifetime,and improved their life quality.