Objective:To explore the role of eptin and adiponectin in the pathogenesis of preeclampcia.Methods:Choosing 38 PE patients as research group,including 16 patients with mild preeclapcia(MPE,group B) and 22 patients with severe preeclapcia(SPE,group C),choosing 40 normal pregnant women(NPW) who deliver in the corresponding period as contrast group(group A).The serum levels of leptin were measured using radioimmunoassay.The serum levels of adiponectin were measured using the enzyme-linked immunosorbent,urine protin and kidney function were measured meanwhile.Results:(1)The serum levels of leptin and adiponectin in three groups were all significantly different in statistics(P<0.05).The serum levels of leptin in women with SPE was maximal,those with MPE was medium,those NPW was minimum;while the serum levels of adiponectin in women with SPE was minimum,those with MPE was medium,those with NPW was maximal.(2)There was a highly negative correlation between the serum levels of leptin and adiponectin in PE patients(r=-0.825,P<0.01).Conclusions:Leptin and adiponectin may be involved in the pathogenesis of PE,moreover,high serum levels of leptin and low adiponectin are associated with the occurrence and elovement of this disease.