Objective:To further explore the factors in their own free urticaria,the pathogenesis of eczema.Methods:We took autologous serum skin test (ASST) of 135 cases of urticaria,79 cases of eczema patients and 20 healthy people tested.Results:214 cases of eczema in patients with urticaria ASST have detected 68 cases of positive,positive rate was 31.8%,the health of the control group were negative,there were differences between two groups (P<0.05).One urticaria and eczema in patients with positive rates were 37.0% and 22.8% (P<0.05),acute phase and non-acute patients with positive rates were 21.3% and 38.1% (P<0.05).Conclusions:In some patients with urticaria and eczema with serum antibodies that exist in their own diseases were involved in autoimmune mechanism.Autoimmune urticaria factor in the incidence of eczema was more meaningful and more important one.