Objective:To discuss the distribution of the pathogens,the resistance pattern,and the counter measure of nosocomial pneumonia.Methods:The analysis of the distribution and the resistance of pathogens was conducted in retrospect of the 52 strains separated from the sputum of 48 patients of nosocomial pneumonia in cadre sickrooms of Maanshan central hospital.Results:The five most common pathogens in the analysis respectively were: Staphylococcus aureus 21.15%,Escherichia coli 17.30%,pseudomonas aeruginosa 15.38%,Acinetobacter baumannii 13.46%,Klebsiella pneumonia 11.54%.According to the drug sensitive test,all antimicrobial-resistant bacilli were increasing.None of the vancomycin-resistant MRSA variant was seen.Conclusions:As regard to nosocomial pneumonia,the most common pathogens are Staphylococcus aureus,Escherichia coli,pseudomonas aeruginosa,Acinetobacter baumannii.In the course of treatment,effective and infection-control procedures,surveillance systems and appropriate antimicrobial selection must be emphasized so as to limit nosocomial pneumonia pathogen occurrence.