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电子期刊 >> 正文 |
| 罗格列酮降低糖尿病肾病患者蛋白尿的疗效观察 |
| 作者：张雪 |
| 单位：攀钢密地医院内一科 |
| 关键词：糖尿病肾病 蛋白尿 罗格列酮 |
| 分类号： |
| 出版年,卷(期):页码：2009,26(3):263-264 |
| 摘要： |
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目的:探讨罗格列酮减少糖尿病肾病患者蛋白尿的疗效。方法:120例糖尿病肾病患者按蛋白尿定性分为轻度(±～+)32例、中度(++)48例、重度(+++～++++)40例共3组,每组又平均分为观察组和对照组,分别予ACEI/ARB及ACEI/ARB联合罗格列酮治疗,疗程6个月,观察两组蛋白尿减少程度及减少时间。结果:观察组患者尿蛋白下降程度较对照组患者显著(P<0.05或P<0.01),而且尿蛋白下降人数达观察人数的半数所需时间均明显短于对照组(P<0.01)。结论:罗格列酮能显著降低糖尿病肾病患者蛋白尿程度,并能减少蛋白尿转阴时间。 |
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Objective:To observe the effect of rosiglitazone on albuminuria reduction in diabetic nephropathy patients.Methods:120 patients of diabetic nephropathy were divided into three groups by urine protein level.Each group was randomized into ACEI/ARB treatment group and rosiglitazone + ACEI/ARB treatment group.All patients were followed up half years to observe the time and degree of albuminuria reduction.Results:Both ACEI/ARB treatment and rosiglitazone+ACEI/ARB treatment could lead protein in urine disappear in diabetic nephropathy patients with mild albuminuria.Rosiglitazone+ACEI/ARB treatment could shorten the time of albuminuria reduction significantly.Conclusions:Rosiglitazonean could shorten the time of albuminuria reduction in diabetic nephropathy patients when used with ACEI/ARB. |
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