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电子期刊 >> 正文 |
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摘要：
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在肿瘤的发生、发展过程中,癌基因与抑癌基因扮演着重要的角色,然而,单个基因的改变不足以造成细胞的完全恶性转化,而是多种癌基因与抑癌基因形成复杂的调控网络共同作用于肿瘤细胞.垂体瘤转化基因(PTTG)是新近发现的癌基因,可通过多种途径参与肿瘤的病理过程.
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作者简介：
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参考文献：
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Pei L.Melmed S Isolation and characterization of a pituitary tumor transforming gene(PTTG) 1997 Kannkis D.Kirches E.Mawrin C Promoter mutations are no major cause of PTTG overexpression in pituitary adenomas 2003(2) Chien W.Pei L A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor transforming gene product 2000(25) Stratford AL.Boelaert K.Tannahill LA Pituitary tumor transforming gene binding factor:a novel transforming gene in thyroid tumorigenesis 2005(7) Pei L Activation of mitogen-activated protein kinase cacade regulates pituitary tumor transforming gene transactivation function 2000(40) Wang Z.Yu R.Melmed S Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia,thymic hyperplasia,thrombocytopenia,aberrant cell cycle progression,and premature centromere division 2001(11) Chesnokova V.Kovacs K.Castro AV Pituitary hypoplasia in pttg -/-mice is protective for Rb +/-pituitary tumorigenesis 2005(9) Kim D.Pemberton H.Stratford AL Pituitary tumor transforming gene (PTTG) induce genetic instability in thyroid cell 2005(30) Pei L Identification of c-myc as a down-stream target for pituitary tumor transforming dene 2001(11) Zhou Y.Mehta KR.Choi AP DNA damage-induced inhibition of securin expression is mediated by p53 2003(1) Bernal J A.Luna R.Espina A Human securing interacts with p53 and modulates p53 mediated transcriptional activity and apoptosis 2002(2) Jung CR.Yoo J.Jang YJ Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo 2006(5) Yu R.Heaney A P.Lu W Pituitary tumor transforming gene cause saneuploidy and p53 dependent and p53 independent apoptosis 2000(47) Hamid T.Kakar SS PTTG/securin activate sex pression of p53 and modulates its function 2004(1) Ishikawa H.Heaney AP.Yu R Human pituitary tumor transforming dene induces angiogenesis 2001(2) 陈凌.刘运生.王陆申.尹海贵.侯庆田.刘志雄.陈立华.凌锋 垂体肿瘤转化基因、内皮抑素和碱性成纤维细胞生长因子mRNA在侵袭性垂体腺瘤中的表达 [期刊论文] -中南大学学报（医学版）2004(6) Hamid T.Malik MT.Kakar SS Ectopic expression of PTTG1/securing promotes tumorigenesis in human embryonic kidney cells 2005(1) Saez C.Martinez-Brocca MA.Castilla C Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer 2006(4) Chen G.Li J.Li F Inhibitory effects of anti-sense PTTG on malignant phenotype of human ovarian carcinoma cell line SK-OV-3 2004(4) Solbach C.Roller M.Peter M Pituitary tumor-transforming gene (PTTG):a novel target for anti-tumir therapy 2005(1A)
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