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电子期刊 >> 正文 |
| 微血管生成及细胞增殖在宫颈癌发生中的作用 |
| 作者：陈雁南 孔红霞 CHEN Yan-nan KONG Hong-xia |
| 单位：郑州大学第三附属医院暨河南省妇幼保健院妇产科 河南郑州 450002 |
| 关键词：血管生成 增殖细胞核抗原 宫颈癌 微血管密度 |
| 分类号：R73 |
| 出版年,卷(期):页码：2007,24(1):0-0 |
| 摘要： |
| 目的:探讨Endoglin及PCNA在宫颈癌的发展中的作用及相互关系.方法:免疫组化SP法检测32倒正常宫颈、31例宫颈癌、34例宫颈上皮内瘤样病变中Endoglin和PCNA的表达,并计算出微血管密度(MVD)和增殖指数(PI).结果:Endoglin及PCNA与宫颈癌的分级和FIGO的临床分期有密切关系.宫颈上皮内瘤样病变程度与MVD和PI表达呈正相关(P＜0.05).宫颈癌的恶性度和FIGO临床分期与MVD、PI呈正相关(P＜0.05).结论:血管形成参与了宫颈癌的发展;Endoglin和PCNA与宫颈癌恶性程度密切相关. |
| 基金项目： |
| 作者简介： |
| 参考文献： |
| Parkin DM.Pisani P.Feflay J Global cancer statistics.Global cancer statistics 2005(2) Folkman J Angiogenesis and tumor growth 1995(26) Guidi A J.Abu Jawdeh G.Berse B Vascular perm ability factor(vascular endothelia growth factor)expression and angiogenesis in cervical neoplasia 1995(16) Weidner N.Folkman J.Pozza f Tumor angtigenesis A new singnificant and independent prognositic factor in early-stage breast carcinoma 1992 Guidi A J.Abu Jawdeh G.Berse B Vascular perm ability factor (vascular endothelia growth factor) expression and angiogenesis in cervical neoplasia 1995(16) Txujiahshi H.Naranishi A.Matsuda H Cell proliferation of human bladder tumors determined by BrdUrd and Ki-67 immunostaining 1991(4) Dietrich DR Toxicological and pathological applications of PCNA,a novel endogenous marker for cell proliferation 1993(1) Brewer CA.Setterdahl JJ.Li MJ Endoglin expression as a measure of micro vessel density in cervical cancer 2000 Btavo R.Frank R.Blundell PA Cyclin / PCNA is the auxillary protein of DNA polymerase-delta 1987(6112) |
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《中国冶金工业医学杂志》 |