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电子期刊 >> 正文 |
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摘要：
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目的:探讨人乳腺癌中真核细胞起始因子-4E(eukaryotic initiation factor 4E,eIF-4E)对特异性淋巴管内皮生长因子VEGF-C(vascular endothelial growth factor C)表达和淋巴转移的影响.方法:分别应用Westen-blot法和免疫组化SP法检测57例乳腺癌组织中eIF-4E蛋白水平及VEGF-C表达,VEGFR-3抗体免疫染色计数乳腺癌微淋巴管密度(lymphatic microvessel density,LMVD).结果:34例淋巴结阳性组织中eIF-4E水平显著高于淋巴结转移阴性组(10.11±0.30,5.94±0.23,t=5.37,P＜0.01).VEGF-C在淋巴结阳性组染色强度明显增高(4.20(0.98),同时VEGFR-3阳性淋巴管密度提高(25.28±5.33),与淋巴结阴性组(2.57±0.88,17.40±4.87)比较差异显著(t=2.18,2.41,P＜0.05).相关分析表明,eIF-4E水平与VEGF-C表达及淋巴结转移呈正相关.结论:eIF-4E可能通过上调VEGF-C的表达诱导乳腺癌淋巴管的生成,进而调控乳腺癌淋巴结转移.eIF-4E可作为判定乳腺癌淋巴结转移的参考指标.
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参考文献：
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Stacker SA.Baldwin ME.Achen MG The role of tumor lymphangiogenesis in metastatic spread 2002(9) Schoppmann SF.Fenzl A.Nagy K VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer:impact on lymphangiogenesis and survival 2006(6) Li YS.Kaneko M.Amatya VJ Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast 2006(5) Graff JR.Zimmer SG Translational control and metastatic progression:enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs 2003(3) De Benedetti A.Graff JR eIF-4 E expression and its role in malignancies and metastases 2004(18) ByrnesK.White S.Chu Q High eIF 4 E,VEGF,and microvessel density in stage Ⅰ to Ⅲ breast cancer 2006(5) Fromowitz FB.Viola MV.Chao S Ras p21 expression in the progression of breast cancer 1987 Weidner N.Folkman J.Pozza F Tumor angiogenesis:a new significant and independent prognostic indicator in early-stage breast carcinoma 1992(24) Chen CN.Hsieh FJ.Cheng YM Expression of eukaryotic initiation factor 4E in gastric adenocarcinoma and its association with clinical outcome 2004(1) Yoon SO.Shin S.Lipscomb EA A novel mechanism for integrinmediated ras activation in breast carcinoma cells:the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling 2006(5) McClusky DR.Chu Q.Yu H A prospective trial on initiation factor 4E (eIF4E)overexpression and cancer recurrence in nodepositive breast cancer 2005(4)
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