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电子期刊 >> 正文 |
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摘要：
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目的:了解宫颈癌Epstein-Barr病毒(EBV)感染情况及错配修复基因hMLH1表达在宫颈癌发生、发展中的意义.方法:采用免疫组织化学SP法检测临床资料较完整的72例子宫颈鳞癌和31例慢性宫颈炎组织EBV潜伏期膜蛋白(LMP1)与hMLH1蛋白表达,并分析二者的相关关系.结果:在宫颈炎及宫颈癌组EBV(LMP1)的表达率分别为90.3%(28/31)和69.4%(50/72),差异显著(P＜0.05);hMLH1的表达率分别为61.3%(19/31)和58.3%(42/72),无显著差异(P＞0.05); EBV感染组和非EBV感染组hMLH1的表达率分别为67.5%(54/80)和43.5%(10/23);差异显著(P＜0.05); EBV(LMP1)和hMLH1的表达率与宫颈癌的分级、分期及淋巴结转移均无明显相关关系(p＞0.05);与是否绝经无明显相关关系(P＞0.05).结论:宫颈炎和宫颈癌EBV感染率均较高,宫颈炎患者宫颈上皮EBV感染可能为致宫颈癌的高危因素,有待于进一步证实.EBV感染时hMLH1表达率增高,提示EBV感染引起的宫颈细胞基因突变增多可能为EBV的致癌机制之一.
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作者简介：
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参考文献：
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郭丰 EB病毒感染与子宫颈癌 [期刊论文] -肿瘤防治研究1998(2) Thoe SY.Wong KK.Pathmanathan R Elevated secretory IgA antibodies to Epstein-Barr virus(EBV)and presence of EBV DNA and EBV receptors in patients with cervical carcinoma 1993(2) Sasagawa T.Shimakage M.Nakamura M Epstein-Barr virus(EBV) genes expression in cervical intraepithelial neoplasia and invasive cervical cancer:a comparative study with human papillomavirus(HPV) infection 2000(3) Lopez-Rios F.Miguel PS.Bellas C Lymphoepithelioma -like carcinoma of the uterine cervix 2000(5) Elgui de Oliveira D.Furtado Monteiro TA.Alencar de Melo W Lack of Epstein-Barr Virus infection in cervical carcinomas 1999(11) Kwasniewska A.Gozdzicka-Jozefiak A.Postawski K Evaluation of DNA mismatch repair system in cervical dysplasias and invasive carcinomas related to HPV infection 2002(3) Chung TK.Cheung TH.Wang VW Microsatellite instability,expression of hMSH2 and hMLH1 and HPV infection in cervical cancer and their clinico-pathological association 2001(2)
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