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电子期刊 >> 正文 |
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摘要：
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目的:探讨上皮性卵巢癌中E2F1的表达及其临床意义.方法:采用免疫组化的技术对正常卵巢组织、卵巢良性肿瘤、交界性卵巢肿瘤、原发上皮性卵巢癌中E2F1的表达进行检测,并结合临床病理资料通过统计学方法分析其表达情况,以及其与正常卵巢组织、卵巢良性肿瘤、交界性卵巢肿瘤及与原发上皮性卵巢癌的分期、病理分型、淋巴结转移、远处转移之间的相互关系.结果:在正常卵巢组织、良性卵巢肿瘤组织、交界性卵巢肿瘤及原发上皮性卵巢癌组织中的阳性表达率分别为16.7%(1/6)、40%(4/10)、60%(6/10)、81.3%(26/32),差异有显著性(P＜0.05).原发上皮性卵巢癌组织中E 2F1的表达在不同的临床病理特征之间差异无显著性(P＞0.05).结论:原发上皮性卵巢癌中E2F1属于癌基因,其超袁达和反常表达与原发上皮性卵巢癌的发生有关.
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参考文献：
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Slansky JE.Farnham PJ Introductior to the E2F family:protein structure and gene regulation 1996 DeGregori J.Leone G.Miron A Distinct for E2F proteins in cell growth control and apoptosis 1997 Lukas J.Petersen BO.Holm K Deregulated expression of E2F family members induces S-phase entry and overcomes P16INK4A-mediated growth suppression 1996 Mann DJ.Jones NC E 2 F-lbut not E 2 F-4 can overcome P 1 6-induced G cell-cycle arrest 1996 Yamasaki L Balancing proliferation andapoptosis in vivo,the Goldilocks theory of E2F/Dpaction 1999 Yasui W.Naka K.Suzuki T Expression of P27Kipl,cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma 1999 Suzuki T.Yasui W.Yokozaki H Expression of the E2Ffamily in human gastrointestinal carcinomas 1999 Balasubram anian S.Ahmad N.Mukhtar H U pregulation of W2F transcription factors in chemically induced mouse skin tumors 1999(2) Lai R.Medeiros LJ.Wilson CS Expression of the cell-elated proteins E2F-1,p53,mdm-2,p21waf-1,and Ki-67 in multiple myeloma:correlation with cyclin-D1 immunoreactivity 1988(7) Rabbani F.Richon VM.Orlow I Prognostic significance of transcription factor E2F-1 in bladder cancer.genotypic and phenotypic characterization 1999(10)
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