Objective:To investigate relationship between ECG ST-T changes and the coronary artery disease.Methods:318 cases with coronary angiography were included in our hospital dated from March 2008 to March 2009,and their referring ECG data were analyzed retrospectively.Results:157 cases were diagnosed with coronary heart disease,including 54 cases with single-vessel lesions and 103 cases with multi-vessel(two or more)lesions;and the other 161 cases of the total 318 patients were considered as control group.There were 256 cases with ECG ST-T changes and 106 of which in coronary heart disease group.The sensitivity and specificity of ECG in diagnosis of coronary heart disease were 41.4% and 67.5%,respectively.The detection rates of ECG in single-vessel group(77.8%)and multi-vessel group(62.1%)were of significant difference(P<0.05).Conclusions:ECG ST-T changes had high specificity in diagnosis of coronary heart disease and could be used for screening.Although they were of less sensitivity and high false negative rate,especially in multi-vessel lesions,they could be used in combination with clinical manifestations.