Objective:To observe the efficacy and toxicity of the combination carboplation-gemcitabine in elderly patients with advanced non-small cell lung cancer(NSCLC).Methods:From November 2005 to December 2007,41 patients were included.Median age was 69(65⁷5).Treatment consisted of gemcitabine 1100mg/m2 on days 1 and 8,and carboplation(AUC=4)on day1,every 21 days.Efficacy was evaluated affter 2 cycles.Results:Overall response rate(ORR)for all patients was 41.5%,ORR for chemotherapy na ve(1st line)and pretreated(2nd line)patients were 50% and 31.6%,respectively.No significant difference was observed between the two groups(P>0.05).The median overall survival was 9.1 mouths and 1-year survival rate was 37.5% for all patients.Conclusions:The combination carboplatin-gemcitabine at these doses was feasible in elderly patients with advanced NSCLC.Tolerability and toxicity were acceptable.