Objective:To evaluate the clinical toxicity and efficacy of Kanglaite injection combined with concurrent chemora-diotherapy in the treatment of locally advanced non-small cell lung cancer.Methods:Forty-eight patients with locally advanced non-small cell lung cancer were randomized into two groups.The combination group received chemotherapy of NVB+DDP regimen,radio-therapy was given with conventional fraction in 2Gy per fraction and five fractions per week.The total tumor doses were 56～60Gy.Combined with Kanglaite injection 200 ml/d for consecutive twenty-one days for two courses,and the control group was chemoradiother-apy only.Toxicities and effects were evaluated according to the criteria of WHO.Results:The CR in combination group and control group were 20.0% and 13%,respectively(P>0.05).Response rate of combination group was 80.0% and 69.5% in control group(P>0.05).Grade 3～4 leukocytopenia,grade 3～4 digestive system and grade 3～4 radiation esophagitisin combination group and control group were 40.0%,8.0%,16.0% and 69.6%,34.8%,43.5%,respectively(P<0.05).KPS and bodyweight score significantly increased in combination group after the combinedtreatment(P< 0.05).Conclusions:Kanglaite injection combined with concurrent chemoradiotherapy could relieve side effects of chemo-radiotherapy in the treatment of locally advanced non-small cell lung cancer,and improved life quality.Kanglaite could increase effectiverate of locally advanced non-small cell lung cancer combined with concurrent chemoradiothrapy.