Objective:To estimate the changes of serum markers in fibrogenesis during treatment of interferon α-2b for chronic hepatitis C.Methods:Forty eight patients with chronic hepatitis C received intramuscular injection interferon α-2b for 6 months.The serum levels of hyaluronate(HA),laminin(LN),type Ⅲ procollagen pepide(PⅢP),and type Ⅳ collagen(C-IV)were measured before(0 month),at the end of interferon alfa therapy(6 months),and the 6th month after the therapy(12 months)in these patients by using enzyme linked im MU nosorbent assay(ELISA).Results:The serum levels of HA,LN,PⅢP,and C-IV in sustained complete response(CR-S) and complete response with rebound(CR-R) groups were significantly lower than those levels in nonresponse(NR) group(P<0.05).The serum levels of HA,LN,PⅢP,and C-IV levels in CR-S significantly decreased after the therapy(P<0.05).These levels remained abnormally high in the CR-R and NR groups.Conclusions:Interferonα-2b therapy could lower the levels of the markers in hepatic fibrogenesis with the improvement in symptoms in hepatic inflammation.