Objective:To observe relation in the type2 diabetes mellitus(T2DM)patients between the glycosylated hemoglobin(HbA1c) and anxiety-depression state.Methods:Totally 86 patients with anxiety-depression state were selected from 382 T2DM patients through psychological CT test.The relative factors about anxiety-depression states were investigated and anti-anxiety/anti-depression treatment were carried out in 67 patients who received whole course following(treatment group n=67).Results:The T2DM patients following anxiety-depression are associated with varied factors.More obvious change of HbA1c and hs-CRP were observed in the treatment group.Conclusions:The psychological problem in the T2DM patients is relationed to anxiety-depression,anti-anxiety/anti-depression treatment is one of the effective treatments methods controlling blood sugar level for the T2DM patients.