To observe the expression of the related tumor markers—cytokeratins(CYFRA21\|1),squamous cell carcinoma antigen(SCC),neuron specific enolase(NSE) and tumor necrosis factor(TNF)in coke oven worker's serum and to analyze its clinical significance.Methods:The experimental group was composed of 35 subjects who exposed to emissions in coke oven for 3 or more than 3 years(COEs exposed population),The contrast group was composed of 35 subjects come from repair department and administration department(COEs non\|exposed population),making the compulsory routine occupational health examination while collecting fasting venous blood,used the enzyme linked immunosorbent assay(ELISA) to detect the level of the tumor makers in the serumCompared the tumor makers which from the exposed group with the contrast group,compare the working age,the oven\|top group and the oven\|side group.Results:The levels of the tumor markers\|\| CYFRA21\|1 and NSE which from the exposed population were higher than the non\|exposed population(P＜001);in the work place team,the levels of the CYFRA21\|1 and NSE which from the oven\|top group were higher than the oven\|side group(P＜005);in the work age team,the levels were increased along with the exposed age(P＜005),the difference had statistical significanceConclusions:The CYFRA21\|1,SCC,NSE and TNF of the coke oven workers serum were positive expression showed different degreesThe study could imply technology support for routine test of COEs exposed and related healthy damage degree; imply scientific support for reducing the exposing of COEs and related coke oven workerslung cancer