中国冶金工业医学杂志

肠易激综合征患者结肠黏膜中MC与VIP的表达

作者：陈吉白晓茹韩明华

分类号：R 574.62

出版年,卷(期):页码：2010,27(6):621-622

摘要：

目的：探讨肥大细胞(MC)与血管活性肠肽（VIP)在肠易激综合征（IBS）患者结肠黏膜中的表达情况及二者的联系，为神经\|内分泌\|免疫网络分析IBS的发病机制提供一定理论依据。方法：选取腹泻型和便秘型IBS患者及正常对照者各20例，对其结肠黏膜活检标本进行免疫组化SABC法和甲苯胺蓝法染色后，对比观察MC和VIP表达情况。结果：IBS患者回盲部和乙状结肠部MC数和VIP免疫阳性神经纤维数均较对照组显著增多(P＜001)，而且IBS患者回盲部MC数和VIP免疫阳性神经纤维均较乙状结肠部MC数和VIP免疫阳性神经纤维明显增多。结论：MC和VIP可能参与IBS的病理生理过程。

Abstract Objective:The expression of Mast Cell(MC)and Vasoactive Intestinal Peptide(VIP)and in colonic mucosa in irritable bowel syndrome(IBS)patients,and its internal relations,for neural-endocrine-immune network analysis of the pathogenesis of IBS provides a theoretical basisMethods:We selected the IBS patients of diarrhea-predominant IBS(D-IBS),constipation-predominant IBS(C-IBS)patients and healthy controls each 20 casesMC with toluidine blue staining,the determination of VIP with Immunohistochemical methodsResults:IBS patients was the more remarkably number of MC in both ileocecal,sigmoid colon mucosa than the normal control group(P＜001),IBS patients were the more remarkably number of positive nerve fibers VIP in both ileocecal,sigmoid colon mucosa than the normal control group(P＜001)Conclusions:MC and VIP might be involved in the pathophysiology of IBS

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作者简介：

参考文献：

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