中国冶金工业医学杂志

辛伐他汀治疗老年高血压伴高脂血症的疗效观察

作者：韩淑萍李薇

单位：四川康骨医院四川成都 610041

分类号：544.1

出版年,卷(期):页码：2010,27(6):635-636

摘要：

目的：观察辛伐他汀治疗老年高血压伴高脂血症患者的临床疗效。方法：将84例确诊的老年高血压伴高脂血症患者随机分为两组，各42例；两组均采用常规降压治疗方案，观察组在此基础上加服辛伐他汀片20 mg，每日晚间顿服，12周为1个疗程；比较两组患者治疗前后动态血压及降压平滑指数的变化情况。结果：疗程结束时，观察组收缩压较治疗前明显降低(P＜001)，且较对照组亦明显降低（P＜005）；观察组降压平滑指数较对照组明显增高（P＜001）。结论：老年高血压伴高脂血症患者在予常规降压药物治疗的基础上，予调脂药辛伐他汀可产生协同降压作用，较单纯降压治疗能够更明显地提高降压平滑性。

To study the effect of simvastatin tablets in treating geriatric hypertensive in senile patients with hyperlipemicMethods:84 patients with hypertension\| hypolipidemic were divided into two groups:the treatment group(n=42)(simvastatin and conventional antihypertensive treatment)and the control group(n=42)(conventional antihypertensive treatment)The course of treatment was 12 weeks24 hours dynamic monitoring of blood pressure were done for all patients in order to compare the change of blood pressure and antihypertensive smoothness index before or after treatments in two groupsResults:Systolic blood pressures(SBP)in patients of treatment group were decreased more significantly after treatment than before;Compared the control group,SBPs were more decreased,but smoothness indexes(SI)were increased significantly in the treatment groupConclusions:For the patients of hypertension\| hypolipidemic,simvastatin with conventional antihypertensive treatment were more effective than only conventional antihypertensive treatmentSimvastatin can present some synergy effect on conventional antihypertensive treatment and improve antihypertensive smoothness

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参考文献：

1彭强，苏海血脂异常与高血压的关联\[J\]中华高血压杂志，2007，15（10）：874\|877
2孙宁玲，徐成斌今日高血压\[M\]北京：中国医药科技出版社，1999:441
3中华心血管疾病杂志编辑委员会血脂异常防治对策专题组血脂异常防治建议\[J\]中华心血管病杂志，1997，25（3）：169\|175
4齐科研，黄慧，吕泽平，等血脂异常与高血压的关联研究\[J\]中国老年保健医学，2009，7（1）：43\|45
5Borghi C， Dormi A， Vorncsi M，et alUse of lipid lowing drugs and blood pressure control in paitents with arterical hypertension\[J\]Clin Hypertension，2002，34（4）：1\|9
6陈月云，章辉，朱正才，等阿托伐他汀对不同血脂水平高血压患者血管内皮功能的影响\[J\]高血压杂志，2005，13：88\|92

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