中国冶金工业医学杂志

多奈派齐联合尼莫地平治疗脑梗死后轻度认知障碍的临床观察

作者：朱双成闾建辉岑跃南

分类号：R 743.33

出版年,卷(期):页码：2010,27(6):639-640

摘要：

目的：观察多奈派齐联合尼莫地平治疗脑梗死后认知功能障碍的临床疗效。方法：将128例脑梗死后认知功能损害患者随机分为2组，治疗组予尼莫地平片30 mg口服3次/日及多奈派齐片5 mg口服1次/日，疗程12周；对照组仅予尼莫地平片30 mg口服3次/日，疗程12周。观察两组治疗后血管性认知功能障碍的改善情况，并应用MOCA评价疗效。结果：治疗12周后，治疗组在定向力、记忆力、计算力、语言能力、执行力等项目的分值要高于对照组，差异有统计学意义(P＜005)。结论：多奈派齐联合尼莫地平治疗脑梗死后认知障碍作用明显，早期应用可预防及延缓痴呆的发生。

To study the therapeutic effect of Donepezil combination with Nimodipine on Patients with Vasculal Cognitive Impairment after Cerebral InfarctionMethods:One hundred and twenty\|eight patients with Vasculal Cognitive Impairment after Cerebral Infarction were divided into randomly into 2 groups，the treating group was treated with Donepezil 5mg／d for 12 weeks，combined by Nimodipine 30mg tid for 12 weeks；the control group was only treated with Nimodipine 30mg tid for 12 weeksThe Efficacy was assessed by the Mini\|Mental State Examination(MoCA)Results:The therapeutic outcomes were better in the treating group than the that in the control group obviously(P＜005)Conclusions:Donepezil combination with Nimodipine had an obvious therapeutic effect on Patients with Vasculal Cognitive Impairment after Cerebral Infarction，therefore it could prevent and delay Dementia occurring at the forepart

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参考文献：

1贾建平重视血管性认知障碍的早期诊断和干预\[J\]中华神经科杂志，2005，38(1)：4\|6
2中华医学会神经科分会各类脑血管病诊断要点\[J\]中华神经科杂志，1996，29(6)：379\|380
3王炜，王鲁宁蒙特利尔认知评估量表在轻度认知损伤患者筛查中的应用\[J\]中华内科杂志，2007，46(5)：414\|416
4Hachinski V，ladecola CPetersen RC，et alNational Institute of Neurological Disorders and Stroke—Canadian Stroke Network vascular cognitive impairment harmonization standards\[J\]Stroke，2006,37：2220\|2241
5Kavi an H，Schneider LSEfficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia：a meta analysis of randomized controlled trials\[J\]Lancet Neurol，2007,6：782\|792
6Pantoni L,Delser T,Soglian AG,et alEfficacy and safety on nimodipine in subcortical vascular dimentia：a randomized placebal controlled trial\[J\]Stroke,2005,36：619\|624

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