Abstract: Objective To clarify the positive adjustment effect by the experimental study of the effect of keyouling on expression of sFas and CD226 in the NK cell of the patients with condyloma acuminata(CA).Methods After isolated the NK cell from the peripheral blood of 80 male CA patients by Ficoll-Hypaque centrifugation, the NK cell was cultured with different dosage of keyouling.To determine the expression of sFas and CD226 in the NK cell by means of ELISA after cultured 48 and 96 hours.Results The expression of sFas in NK cell l had been significantly reduced by the high dosage of keyouling after cultured 48 hours.The expression of CD226 in NK cell l had been significantly reinforced by the high dosage of keyouling after cultured 48 hours.There were no significant difference of all the above detail compared with the group of IL-15（P＜0.05）,but there were significant difference compared with the groups of the low dosage of Keyoulingand and blank control group（P＜0.05，P＜0.01）.Conclusion The high dosage of keyouling could reduced the abnormal apoptosis of the NK cell of the patients with CA.It had significant positive immune adjustment effect.