Abstract: Objective To explore the clinical features and outcomes of patients with cerebral venous sinus thrombosis(CVT)during pregnancy and puerperium.Methods  A retrospective study was performed in 12 cases of pregnant women with CVT among deliveries in our hospital from January 2001 to January 2010,including 2 cases happened during pregnancy and 10 cases during puerperium.The etiology,clinical presentations,imaging examination results,other relevant examinations and pregnant outcomes of these patients were analyzed.Results (1)Incidence of CVT during pregnancy and puerperium was 0.17‰(12/68000)and incidence of CVT in severe preeclampsia / eclampsia was 5.63‰(10/1775).(2)The time of the patients fell ill was during preoperation to 24 hours after cesarean section.The first symptom mostly was headache,nausea and vomiting or blind.With the different location of CVT,the signs were different,such as hyperspasmia,myasthenia hemiplegia papilledema and positive pathological reflex.All women showed superior sagittal sinus thrombosis by CT examinations.Conclusion  The patients of severe preeclampsia/eclampsia often fell in CVT during pregnancy and puerperium.The time of the patients fell ill from preoperation to 24 hours after cesarean section.The first symptoms often were headache,nausea and vomiting or blind.The signs were different,such as hyperspasmia and myasthenia,hemiplegia,papilledema,positive pathological reflex.When obstetric medicine couldn't control spasm,we should alert CVT,do the imaging examination such as CT、MR and treat it as early as possible.Plasma D\|dimer,Fibrinogen and HDL\|C may be used to forecast CVT.