Abstrac:Objectivet:To compare the clinical features of pulmonary tuberculosis(TB)and TB with fungal infection(FI)in old population, and provide evidence for the prevention and treatment of TB with FI.MethodsWe collected and analyzed the clinical data of patients in our hospital from 2005 to 2010.They were divided into two groups:patients with single TB(group I,166)and patients with TB and FI(group II,140).  ResultsComparing with group I,patients in group II showed worse living conditions,older age,longer duration of disease,more severe clinical manifestations,larger lesions and obvious empty and fibrosis.Besides,the times of hospitalization in group II were more.The proportion of drug resistance of 2 or more anti-TB drugs was 40.2%. Differences between 2 groups were statistically significant.Conclusion The main reasons of TB with FI in old population include:(1)Decreased immunity results from poor living conditions,old age and long duration of disease,(2)TB infects pulmonary issue and causes serious pathological changes, that provides a favorable circumstance for FIs growing,(3)Non-standard treatment, abuse of broad-spectrum antibiotics,corticosteroids and immunosuppressive agents lead to drug resistance and decreased immunity.