中国冶金工业医学杂志

甲基泼尼松龙治疗过敏性紫癜伴消化道出血疗效观察

作者：何英1 李顺品1 张彬2

分类号：中图分类号：R 573文献标志码：A文章编号：1005-5495(

出版年,卷(期):页码：2012,29(3):260-261

摘要：

摘要：目的探讨甲基泼尼松龙治疗过敏性紫癜合并消化道出血的临床效果。方法将43例腹型过敏性紫癜合并消化道出血患儿分为治疗组20例和对照组23例，两组患儿的临床资料无统计学差异，并均采用相同的综合治疗措施；在此基础上，治疗组予甲基泼尼松龙3~5 mg/（kg·d）静脉滴注、对照组予泼尼松1~2 mg/(kg·d)口服，用药至消化道症状消失。观察比较两组患儿治疗后临床效果、应用糖皮质激素的副作用发生率及症状复发率。结果治疗组的腹痛缓解时间为（4.15±1.79）天、血便消失时间为（5.70±1.63）天、禁食时间为（7.10±1.74）天，均显著短于对照组的（5.74±1.84）天、（7.22±1.98）天和(8.57±1.38)天，差异有统计学意义（P＜0.01）；两组出现的糖皮质激素副作用发生率无统计学差异，但对照组复发率则显著高于治疗组（P＜0.05）。结论甲基泼尼松龙治疗腹型过敏性紫癜伴消化道出血效果优于泼尼松，且安全可靠。

Abstract:ObjectiveTo investigate the effect of Mathylprednisolone on patients who suffered from Anaphylactoid purpura with hemorrhage of digestive tract.MethodsThe 34 cases diagnosised as Anaphylactoid purpura with hemorrhage of digestive tract were randomly divided into 2 groups:the control group and the treating group.Each group was treated with the same routine treatments.The Mathylprednisolone3-5mg/(kg.d)were given to the patients in treating group.The prednisone(2mg/kg.d)was given to the control group.Both group were treated till the bloodystool disappeared.The period to improve the symptoms,the rate of recurrence and the side effects of the drug were Compared between 2 groups. ResultsThe period to improve the symptoms in treating group was shorter than control group,the rate of recurrence in treating group was lower than control group,the side effects of the drug in two groups were not significant difference.Conclusion Mathylprednisolone is a more evaluable in the patients who suffer from anaphylactoid purpura with hemorrhage of digestive tract.

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参考文献：

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