Abstract:ObjectiveTo discuss the clinical application of pleural biopsy in pleural plaque lesions.Methods100 cases of CT guided biopsy with pleural plaques were in group A,100 cases of conventional pleural plaque biopsy were in group B.Specimens were sent for histopathological examination after biopsy.ResultsIn A group,the biopsy pathology detection rate was 93% (93 /100),the true positive rate was 88%(88/100),sensitivity of benign and malignant lesions were 9167%(22/24),9296%(66/71),the rate of misdiagnosis were 833%(2/24)and 704%(5/71)respectively.In group B patients biopsy pathology detection rate was 68%(68/100),the positive rate was 65%(65/100),sensitivity of benign and malignant lesions were 6818%(15/22),7042%(50/71),the rate of misdiagnosis were 3182%(7/22)and 2958%(21/71)respectively.Sensitivity and the rate of misdiagnosis in two groups were compared with statistical significance(P＜005).ConclusionThe diagnosis rate and detection rate of pleural plaque lesions could be more improved using CT guided biopsy compared with conventional pleural biopsy.The method is simple,safe,practical,and should be worthy of promoting.