中国冶金工业医学杂志

多烯磷脂酰胆碱联合阿托伐他汀治疗非酒精性脂肪肝疗效观察

作者：肖霞

分类号：R 5751文献标志码：A文章编号：1005-5495(2012)06-0

出版年,卷(期):页码：2012,29(6):627-628

摘要：

摘要：目的探讨多烯磷脂酰胆碱联合阿托伐他汀片治疗非酒精性脂肪肝的疗效。方法50例非酒精性脂肪肝患者在予饮食与运动治疗的基础上，予多烯磷脂酰胆碱456 mg，3次/日口服；阿托伐他汀片10 mg，1次/日睡前口服。疗程为3个月，观察治疗前后患者的肝功能、血脂等指标及临床症状和体征的变化情况。结果治疗后,患者血清中ALT、AST、TBIL均降至正常水平，与治疗前比较有统计学差异(P＜005)；TC、TG、LDL\|C含量较治疗前显著降低(P＜001)；临床总有效率达97％。结论多烯磷脂酰胆碱联合阿托伐他汀片治疗非酒精性脂肪肝临床效果好，能有效地改善患者的肝功能和血脂等指标。

Abstract:Objective To study the curative effect of non\|alcoholic fatty liver disease treated with polyene phosphatidylcholine and atorvastatinMethodsOn the basic of proper diet and exercise,50 patients of diabetes without fatty liver were given polyene phosphatidylcholine orally 456 mg,3 times daily and atorvastatin orally 10mg daily before bedtime for 3 monthsThe relative indices and ultrasound B imaging were observedResultsAfter treatment,23 patients were completely cured,the cure rate was 46%,the total effective rate was 97%The levels of alamine aminotrasferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)were reduced to normal range (P＜0.05) and the total cholesterol(TC),triglyceride(TG),low\|density lipoprotein cholesterol(LDL\|C)levels were remarkably decreased(P＜0.01)ConclusionTreatment with polyene phosphatidylcholine and atorvastatin can effectively improve the index of hepatilic function and blood lipid,and can effectively respite and reverse non\|alcoholic fatty liver disease

基金项目：

作者简介：

参考文献：

［1］中华医学会肝脏学分会脂肪肝和酒精肝病学组非酒精性脂肪性肝病诊断标准\[J\]中华肝脏病杂志，2002，10(2)：72

［2］吴乃森腹部超声诊断与鉴别诊断学\[M\]2版北京：科学技术文献出版社，2001：59\|62

［3］Bai J,Cederbaum AIOverexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione\[J\]Biol Chem,2006,281(8):5128\|5136

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