中国冶金工业医学杂志

胱抑素C、C反应蛋白及尿微量白蛋白联合检测在糖尿病肾损伤诊断中的意义

作者：王金华马丽媛蒋为

分类号：中图分类号：R 5871文献标志码：A文章编号：1005-54

出版年,卷(期):页码：2013,30(1):3-4

摘要：

摘要：目的探讨胱抑素C（CysC）、C反应蛋白（CRP）及尿微量白蛋白（UMA）联合检测在糖尿病肾损伤诊断中的意义。方法选取96例2型糖尿病（T2DM）患者分为两组，其中糖尿病未发生肾脏病变即单纯糖尿病（SDM）组54例，糖尿病肾病（DN）组42例，另设对照组为48例健康体检者。利用全自动生化分析仪检测其静脉血中CysC、CRP及尿中UMA含量，并常规检测肌酐(CRE)的含量做为对照分析。结果SDM组CysC、CRP、UMA与正常对照组比较差异有统计学意义（P＜005），而CRE与正常对照组比较差异无统计学意义（P＞005）；DN组CysC、CRP、UMA与正常对照组及SDM组比较差异有统计学意义（P＜005）。SDM组CysC、CRP、UMA三者联合检测阳性率为91％，显著高于单项检测（P＜005）。结论CysC、CRP、UMA是糖尿病早期肾损伤的敏感指标，监测患者三项指标的动态变化，可以早期发现糖尿病肾损伤，为临床诊治提供依据。

Abstract: Objective To investigate the clinical value of determination of serum Cystatin C and high\|Sensitivity C reactive protein and Urinary albumin in patients with diabetic nephropathy diagnosisMethodsNinety\|six patients with type 2 diabetes mellitus(T2DM)were divided into SDM group(54 cases)without diabetic nephropathy and DN group(42 cases)with diabetic nephropathy and other healthy physical subjects(48 cases)were as control groupCysC,CRP,UMA and CRE were examined by automatic biochemical analyzerResultsIn SDM and DN group,CysC,CRP,UMA were significantly higher than those in the normal control group directly（P＜005）But CRE was higher only in DN groupThe positive rate of combined detection for CysC,CRP,UMA was 91％,obviously higher than that of single testConclusionCysC,CRP,UMA were the sensitive indicators of early kidney damage,and their joint detection would discover kidney damage early which provide evidence for clinical diagnosis

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参考文献：

［1］Mendiluce A,Bustamante J,Martin D,et al Cystatin C as a marker of renal function in kidney transplant patients\[J\] Transplantation Proceedings,2005,37(9):3844\|3847

［2］李静血清胱抑素C对糖尿病早期肾损害的诊断价值评估\[J\]医学信息，2009，22（12）：2751\|2752

［3］胡芳，王学斌，饶锦秀糖尿病早期肾损伤的实验诊断\[J\]华中医学杂志，2007，31（1）：46\|47

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