Abstract: Objective To suboptimal glycemic control in type 2 diabetes patients with insulin treatment three premixed insulin regimen and three short in a programme of clinical application of contrastMethods Patients were randomly divided into 2 groups,100 cases in group A,half an hour before meals to subcutaneous injection of Ganshulin 30R or 50R(with high fasting blood glucose mainly using Ganshulin 30R,to postprandial glucose high mainly using Ganshulin 50R);102cases in group B,half an hour before meals to subcutaneous injection of Ganshulin R and Ganshulin N bedtime injection ,based on blood glucose level adjustment of the insulin dose to achieve target blood glucose valueObservation of the target blood glucose value time,glycosylated hemoglobin,patient compliance,the rate of hypoglycemiaResults Three short and one middle to three times of premixed insulin treatment,although up to a target blood glucose value time is short,but both were not significantly different;in the incidence of hypoglycemia,compliance,glycosylated hemoglobin in the comparison,the three premixed insulin treatment were better than three short in the treatment ofConclusion For suboptimal glycemic control in type 2 diabetic patients with the use of 3 daily subcutaneous injection of insulin in treatment of a three short programmes more easily accepted by the patient and adhere to,in order to achieve its long\|term effective as target blood glucose,to reduce the acute and chronic complications of diabetes