中国冶金工业医学杂志

脐血胆红素对新生儿黄疸早期干预的意义

作者：孙亮杨云

分类号：中图分类号：R 722文献标志码：A文章编号：1005-5495(

出版年,卷(期):页码：2013,30(4):390-391

摘要：

摘要：目的研究脐血胆红素值对新生儿黄疸早期干预的意义。方法对本院240例足月健康新生儿，测定脐血胆红素值，监测每日经皮胆红素值(TCB)，将新生儿按脐血胆红素浓度分＜30 μmol/L；30～40 μmol/L；40～50 μmol/L；＞50 μmol/L，共4组。比较4组新生儿TCB值及病理性黄疸例数，对脐血胆红素浓度预测新生儿黄疽进行分析。比较黄疸组新生儿和非黄疸组新生儿临床特征。结果随着脐血胆红素水平的升高，各组新生儿TCB、TSB值增高，病理性黄疸例数增高，脐血胆红索浓度用于预测新生儿黄疽发生率有统计学意义黄疽组新生儿脐血胆红素值显著高于非黄疸组(χ2=4528,P＜0.01)。经皮胆红素值与脐血胆红素值有高度相关性，(r=+0.871，P＜0.01)。结论脐血胆红素能够对新生儿生前已具潜在原因引起的病理性黄疸予以早发现、早诊断、早治疗。

Abstract:ObjectiveTo investigate the predictive value of umbilical cord blood bilirubin level for subsequent treatment for neonatal jaundiceMethodsTwo hundred and forty healthy term newborns were selectedAll the infants were determined the umbilical cord blood bilirubin concentration and measured of transcutaneous bilirubin dailyThe infants were aligned into four groups according to their umbilical cord blood bilirubin level,starting from＜30 μmol/L；30～40 μmol/L；40～50 μmol/L；＞50 μmol/LTo analysis of umbilical cord blood bilirubin as a predictor of later development of subsequent jaundiceThe characteristics of infants who became jaundiced were compared with the normal infantResultsThe transcutaneous bilirubin levels and pathologic jaundice patients increased with increasing umbilical cord blood bilirubin levelsIt was a significant to predict neonatal jaundice by umbilical cord blood bilirubin levels(χ2=4528,P＜0.01)There was a positive association between transcutaneous bilirubin levels and umbilical cord blood bilirubin levels(r=+0.871，P＜0.01)ConclusionThe use of umbilical cord blood bilirubin level for subsequent treatment for neonatal jaundice might reduce the injury of pathologic jaundice

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参考文献：

[1] 沈晓明,王卫平儿科学[M]7版北京:人民卫生出版社,2008:115

［2］Kirk JMNeonatal jaundice：a critical review of the role and practice of bilirubin analysis J[J]Ann Clin Biochem, 2008, 45 (5) ：452 -462

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