中国冶金工业医学杂志

血清25 OHVD水平在2型糖尿病及其并发的急性冠脉综合征中的变化和与血清CRP、MMP-9、HPA水平的相关性分析

关键词：关键词：2型糖尿病急性冠脉综合征 25羟基维生素Ｄ(25 OHVD） C反应蛋白（CRP）基质金属蛋白酶９（MMP-9）乙酰肝素酶（HPA）

分类号：中图分类号：R 5871文献标志码：A文章编号：1005-54

出版年,卷(期):页码：2013,30(6):625-627

摘要：

摘要：目的探讨血清25羟基维生素Ｄ(25OHVD）水平在2型糖尿病（T2DM）及其并发的急性冠脉综合征（ACS）患者中的变化情况及与血清C反应蛋白（CRP）、基质金属蛋白酶９（MMP-9）和乙酰肝素酶（HPA）水平的相关性。方法选取T2DM患者60例和ACS患者47例为病例组， ACS组中包括不稳定型心绞痛（UAP）27例、急性心肌梗死（AMI）20例；T2DM组中合并ACS（T2DM+ACS亚组）25例，其中合并UAP （T2DM+UAP组)15例、合并AMI（T2DM+AMI组）10例；以同期健康体检者50例为正常对照（NC）组。比较各组血清25OHVD、钙离子（Ca2+）、CRP、MMP-9、HPA水平,并分析血清25OHVD水平与血清CRP、MMP-9和HPA水平的相关性。结果（1）T2DM组血清Ca2+和25OHVD水平较NC组明显降低（P＜0.05），尤其是DM+ACS亚组血清Ca2+和25OHVD水平降低更为明显（P＜0.05），其中T2DM+AMI组患者血清25OHVD水平还低于T2DM+UAP组患者（P＜0.05）。（2）T2DM组与ACS组血清HPA、MMP-9及CRP水平均明显高于NC组（P＜005或P＜0.01）；T2DM+ACS亚组血清HPA、MMP-9和CRP水平明显高于T2DM组（P＜0.05），且T2DM+AMI组血清HPA、MMP-9和CRP水平明显高于T2DM+UAP组（P＜0.05）；AMI亚组血清HPA、MMP-9及CRP水平明显高于UAP亚组（P＜0.01）。（3）T2DM组患者血清25OHVD水平与HPA、MMP-9和CRP水平均呈显著负相关，相关系数分别为-0.783、-0.693和-0.741（P均＜0.01）。结论血清25OHVD在T2DM及其合并ACS的发生、发展中起一定作用,可作为预测T2DM患者动脉斑块不稳定性的指标，为T2DM的防治提供线索。

Abstract:ObjectiveIn this experiment,we investigated the change of serum 25OHVD in 2 diabetes with acute coronary syndrome and the correlation with CRP,MMP-9 and HPAMethodsWe selected 50 cases of healthy control group,and 47 patients with acute coronary syndrome,in whom 27 were with unstable angina pectoris(UAP),and the other 20 were with acute myocardium infarct（AMI）We selected 60 patients with type 2 diabetes,in whom 35 with type 2 diabetes;and 25 were with acute coronary syndrome,including 15 patients complicated with UAP ,and the other 10 patients were complicated with AMIIt compared the serum 25OHVD level in each group whether the levels have statistical differences,also analyzed the relationship with CRP,MMP-9 and HPAResultsSerum calcium and 25OHVD levels were lower in the type 2 diabetes group compared with the healthy control group,and there were statistical differences in each group（P＜0.05）Serum calcium and 25OHVD levels were lower in the type 2 diabetes with ACS group compared with the healthy control group,and he serum CRP,MMP-9 andHPA levels were increased significantly,so there were statistical meaning in each group（P＜0.05）Using multiple regression analysis,25OHVD was negatively correlated with CRP,MMP-9,and HPA in the type 2 diabetesConclusionSerum 25OHVD was play an important role in the department of ACS,can be seen a material to predict the unstability of plaques in the type 2 diabetesProvide clues to more active for diabetes prevention and treatment

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参考文献：

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