ObjectiveIn order to reveal the relationship between cord blood leptin,adiponectin and IGF\|Ⅰ and the fetus growth and development,and discuss the interaction and clinical significance on fetus growth and development.MethodsThe levels of cord blood leptin,adiponectin,IGF\|Ⅰ in 86 newborns were examined by radio immunoassay,according to gestation age and birth weight percentile relation were divided into the SGA group(n=16),the AGA group(n=41),the LGA group(n=29),meanwhile measure neonatal birth weight,body length,head circumference,foot length,placental weight and compute body mass index,results undertake dependability analyze.ResultsThe levels of cord blood leptin,adiponectin and IGF\|Ⅰ all LGA group＞AGA group＞SGA group.The level of cord blood adiponectin was positively correlated with birth weight,placental weight and body mass index(P＜0.05).Cord blood Leptin and IGF\|Ⅰ concentrations separate were positively correlated with their birth weight,body length,head circumference,foot length,placental weight and body mass index (P＜0.01),Leptin were positively correlated with adiponectin and IGF\|Ⅰ(P＜0.01).The levels of cord blood leptin and adiponectin had no statistical significance with neonatal sexuality and deliver style（P＞0.05）；the levels of cord blood IGF\|Ⅰ had no significantly different with neonatal sexuality（P＞0.05）,statistical significance with deliver style(P＜0.05).ConclusionCord blood Leptin,adiponectin and IGF\|Ⅰ played an important part in adjust fetus growth and development,participate in the process of fetus growth and development,could be regarded as one of the clinical indexes to evaluate fetus growth and development or nutrient.The abnormal level of cord blood Leptin,IGF\|Ⅰ might be one of the reasons to cause intrauterine growth retardation and large for date infant occurrence.