中国冶金工业医学杂志

高血压性脑梗死患者血清超敏C反应

作者：杨月明1 韩国栋2 袁利和1

分类号：

出版年,卷(期):页码：2014,31(2):129-131

摘要：

目的探讨高血压性脑梗死患者血清超敏C反应蛋白与动脉粥样硬化之间的关系。方法选取58例高血压性脑梗死患者、46例原发性高血压患者及50例正常对照者，分别检测其血清超敏C反应蛋白及颈动脉粥样硬化指标，进行比较。结果高血压性脑梗死组血清超敏C反应蛋白水平高于原发性高血压组及正常对照组，颈动脉粥样硬化程度明显重于其他两组；高血压性脑梗死有斑块组血清超敏C反应蛋白水平高于原发性高血压有斑块组，差异有统计学意义（P＜005）。结论高血压患者存在明显的炎性反应，而这一反应在高血压性脑梗死患者中更明显。高血压性脑梗死患者血清超敏C反应蛋白与颈动脉粥样硬化存在明显的相关性。及早对高血压患者进行抗炎治疗或许会有助于脑梗死的预防

ObjectiveTo deplore the relationship between serum high\|sensitivity C\|reactive protein(hs\|CRP) and carotid atherosclerosis in cerebral infarction(CI)patients with essential hypertension.Methods58 cases of CI with essential hypertension, 46 cases of essential hypertension and 50 healthy cases were enrolled Serum hs\|CRP levels and carotid atherosclerosis were detected and compared among them.ResultsSerum hs\|CRP level in CI patients with essential hypertension was higher than that in the other two groups,so was the degree of carotid atherosclerosis.The level of serum hs\|CRP with positive plaques in CI patients complicated with essential hypertension was higher than that in essential hypertension patients.The difference had statistically significance (P＜005).ConclusionInflammatory reaction exists in essential hypertension patients,and is more obvious in CI patients complicated with essential hypertension.Hs\|CRP is closely correlated with carotid atherosclerosis plaques,and early anti\|inflammation treatment may be useful in the prevention of CI in essential hypertension patients.

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参考文献：

［1］张梅，张运，高月花，等.超声检查对颈动脉粥样硬化血管重构的研究［J］.中华超声影像学杂志，2002，11(4):229\|231.

［2］Sauriasari R，Sakano N，Wang DH，et al.C\|reactive protein is associated with cigarette smoking\|induced hyperfiltration and proteinuria in an apparently healthy population［J］Hypertens Res， 2010，33(11):1129\|1136.

［3］Amer Moatassem S，Elawam Amal E，Khater Mohamed S，et alAssociation of high sensitivity C\|reactive protein with carotid artery Intima\|media thickness in hypertensive older adults［J］JASH，2011，5（5）：395\|400

［4］王秀艳, 袁建新, 王轶瑾, 等血清超敏C 反应蛋白与急性脑梗死的相关性研究\[J\]临床神经病学杂志, 2006, 19 ( 3 ): 210\|212

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