中国冶金工业医学杂志

培美曲塞二钠联合顺铂一线治疗晚期非小细胞肺癌的临床研究

作者：李强贾晓斌

单位：商洛市中心医院陕西商洛 726000

分类号：R 734.2

出版年,卷(期):页码：2014,31(4):376-378

摘要：

摘要：目的研究培美曲塞联合顺铂与（紫杉醇、吉西他滨或长春瑞滨）联合顺铂组治疗晚期非小细胞肺癌的疗效及不良反应对比。
方法36例晚期非小细胞肺癌患者，分为两组每组18例，一组给予培美曲塞联合顺铂全身化疗，另一组给予（紫杉醇、吉西他滨或长春瑞滨）联合顺铂全身化疗。
结果实验组完全缓解（CR）0例，部分缓解（PR）4例，稳定（SD）10例，进展（PD）4例，总有效率（CR+PR）为22.2%，疾病控制率（CR+PR+SD）为77.8%；对照组完全缓解（CR）0例，部分缓解（PR）3例，稳定（SD）9例，进展（PD）6例，总有效率（CR+PR）为16.7%，疾病控制率（CR+PR+SD）为66.7%。两组相比差异无统计学意义（[WTBX]P[WTBZ]＞0.05）。TTP和OS差异无统计学意义，但在血液毒性及消化道反应方面，实验组低于对照组。
结论培美曲塞联合顺铂一线治疗晚期非小细胞肺癌具有有效、毒性低，且具有较好的耐受性。

Abstract:[BF]ObjectiveTo compare the efficacy and satety of Pemetrexed Disodium combined with Cisplatin and those GEM,PTX or NVB combined with cisplatin for the first\|line treatment of advanced non\|small cell lung cancer.
MethodsThirty\|six cases of patients with advanced non\|small cell lung cancer were randomly divided into two groups.In treatment group,18 patients of advanced NSCLC were received pemetrex and cisplatin.In control group,18 patients of advanced NSCLC were received PTX or GEM or NVB and cisplatin.
ResultsIn treatment group,0 patient showed complete response,4 cases showed partial response(PR),10 cases showed stable disease(SD),4 cases showed progressive disease(PD);the overall response rate was 22.2 %,and the disease control rate was 77.8%.In control group,0 patient showed complete response,3 cases showed PR,9 cases showed SD,6 cases showed PD;the overall response rate was 16.7 %,and the disease control rate was 66.7%.There was no significant difference in overall response rate and disease control rate betwee the two groups([WTBX]P[WTBZ]＞0.05).TTP and OS of the two groups had no significant differences either.Hematological toxicity and gastrointestinal toxicity of treatment group were abviously less than those of the control group.
ConclusionAs the fisrt\|line treatment of advanced non\|small cell lung cancer,pemetrexed disodium combined with cisplatin had more efficacy,lower toxicity and better tolerability.

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参考文献：

参考文献［1］GV Scagliotti,PParikh,Jvon Pawel,et al.Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy\|naive patients with advanced\|stage non\|small\|cell lung cancer\[J\].J Clin Oncol，2008，26：3543\|3551.
［2］GS Longo\|Sorbello,BChen,TBudak\|Alpdogan,et al.Role of pemetrexed in non\|small cell lung cancer\[J\].Cancer Invest,2007，25:59\|66.
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