中国冶金工业医学杂志

血府逐瘀汤对MCI大鼠海马神经递质变化的影响

作者：张晔李屹刘永林周郦楠

分类号：中图分类号：R 74333

出版年,卷(期):页码：2015,32(2):128-130

摘要：

目的探讨多发性脑梗死大鼠应用血府逐瘀汤进行治疗后大鼠海马神经递质的变化。方法制备多发性脑梗死大鼠动物模型，将160只健康雄性Wistar大鼠分为4组，研究大鼠海马神经递质在用药前后的改变。结果术后第7天，中药治疗组与模型组相比较，大鼠海马CA1区存活的神经元数量增多明显(P＜001)，NKB阳性神经元百分率明显增高（P＜001）；中药治疗组术后第7天与术后第1天比较，nNOS阳性神经元数量有所减少（P＜005），NKB阳性神经元百分率显著增高（P＜001）。结论血府逐瘀汤能使多发性脑梗死大鼠海马组织缺血部位有所恢复，对多发性脑梗死的治疗有重要的临床指导意义。

ObjectiveExplore the effect of Xuefuzhuyu decoction in rats with multiple cerebral infarction(MCI)MethodsMCI models were established in wistar rats160 healthy male rats were divided into four groupsThe changes of neurotransmitter before and after treatment of Xuefuzhuyu decoction were studiedResults7 days after operation: compared with that of model group，the number of surviving neurons of hippocampal CA1 area in treatment group increased significantly(P＜001)，the percentage of NKB positive neurons increased significantly(P＜001)In treatment group compared with that of 1 days，the number of nNOS positive neurons at 7 days after operation were decreased（P＜005），the percentage of NKB positive neuron were significantly increased(P＜001)ConclusionXuefuzhuyu decoction can significantly improve ischemic in hippocampus of MCI rats，which shows important significant for treatment of MCI

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参考文献：

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