中国冶金工业医学杂志

VEGF联合CA 125、CEA、HE 4 应用晚期卵巢癌伴恶性腹腔积液患者临床价值探讨

分类号：中图分类号：R 7373

出版年,卷(期):页码：2015,32(2):138-140

摘要：

目的探讨VEGF（血管内皮生长因子）联合CA 125、CEA（癌胚抗原）、HE 4（人附睾蛋白4）检测应用晚期卵巢癌伴恶性腹腔积液患者的临床价值。方法应用ELISA和电化学发光法分别检测146例初治晚期卵巢癌伴恶性腹腔积液患者的腹腔积液和血清的VEGF和CA 125、CEA、HE 4水平，并分别与良性腹腔积液患者进行比较。结果患者腹腔积液和血清中的CA 125、HE 4、VEGF水平均显著高于非癌性腹腔积液患者，P＜005，而CEA在两种体液中水平与良性疾病患者无差异，P＞005；CEA、VEGF在腹腔积液均值、灵敏度和特异度整体表现优于血清，而CA 125、HE 4在血清中均值、灵敏度和特异度整体表现优于腹水；血清、腹水VEGF联合CA 125、CEA、HE 4诊断灵敏度和特异度分别为8025%和7099%，8500%和7633%，而腹水CEA、VEGF加血清CA 125、HE 4灵敏度和特异度可以达到9034% 和8252%。结论行腹腔积液CEA、VEGF和血清CA 125、HE 4联合检测对晚期初治卵巢癌伴腹腔积液患者具有重要的临床价值，是比较可靠的双体液联合诊断模式。

ObjectiveTo explore the clinical value of VEGF and CA125，CEA，HE4 combination test for the patients of ovarian cancer in late stage with malignant ascitesMethodsTo use ELISA and ECLIA method to test levels of VEGF and CA125，CEA，HE4 in 146 cases of untreated patients of ovarian cancer in late stage with malignant ascites and compare them to that of the patients with benign ascites in our hospital from May 2011 to June 2012ResultsThe levels of CA125，HE4 and VEGF were significantly higher than that in patients with benign ascites(P＜005)，while CEA were no significant difference(P＞005);the average value，sensitivity and specificity of CEA and VEGF in ascites were better than that in serum while for CA125,CEA and HE4 in serum were better than that in ascites;the sensitivity and specificity of VEGF combined CA125，CEA and HE4 test in serum and ascites were 8025% and 7099%，8500% and 7633%，and that of combined CA125 and HE4 test in serum with CEA and VEGF test in ascites were 9034%，8252%ConclusionCombination test model of CA125，HE4 in serum and CEA，VEGF in ascites is of great clinical application value for the patients of ovarian cancer in late stage with malignant ascites

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参考文献：

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