ObjectiveTo observe the protective effect of dexrazoxane on acute cardiotoxicity induced by doxorubicin.MethodsIn 96 cases of chemotherapy with doxorubicin,integrated ECG,troponin I,brain natriuretic peptide levels and left ventricular ejection fraction (LVEF) were monitored as observation indexes.After chemotherapy alone for 4 cycles (doxorubicin cumulative dose about 300 mg/m2),the cases of abnormal observation indexes were included in dexrazoxane treatment group,the cases of normal indexes were classified into chemotherapy alone group and chemotherapy combination with dexrazoxane group.All patients received 2 more cycles of chemotherapy,the incidence of acute cardiac toxicity was observed.ResultsThe incidence rate of abnormal observation indexes was 31.3%(30/96)for 4 cycles of chemotherapy alone.Continue two cycles of chemotherapy,incidence rate of abnormal observation indexes in chemotherapy alone group was 39.4%(13/33),15.2%(5/33)in Dexrazoxane combined group.The incidence rate of acute cardiac toxicity in chemotherapy alone group were significantly higher than that in combined with dexrazoxane group (P＜0.05)，the difference was statistically significant;there was 26.7%(8/30)patients with abnormal indicators became normal,63.3%(19/30)patients with abnormal indicators remain stable,and only 10%(3/30) patients with heart damage worse in dexrazoxane treatment group.ConclusionDexrazoxane has protective effect to cardiac toxicity induced by doxorubicin,and have a certain therapeutic effect on damages which have been formed.Key Words:Dexrazoxane；Doxorubicin；Protective effect on acute cardiotoxicity