中国冶金工业医学杂志

心力衰竭患者NT\|proBNP检测的临床意义

作者：张学平王庆山邵宏伟王丹

分类号：R 54

出版年,卷(期):页码：2015,32(5):503-504

摘要：

目的研究HF患者NT\|proBNP检测的临床意义。方法检测60例健康体检者(对照组)和382例HF患者（观察组）及80例HF患者治疗后第7天及第15天血清NT\|proBNP水平。结果观察组血清NT\|proBNP水平显著高于对照组，差异具有统计学有意义（P＜0.01）；观察组心功能分级不同血清NT\|proBNP水平也具有明显差异，具有统计学有意义（P＜0.01），并且随着心功能分级的不断升高，患者的血清中NT\|proBNP 水平浓度也呈现升高的趋势。80例HF治疗患者第7、15天采血检测结果显示：随着心功能持续改善，病人的NT\|proBNP水平持续下降，前后差异具有统计学意义。（P＜0.01）。结论血清NT\|ProBNP水平检测对HF患者的诊断、病情评估和疗效评价有重要临床意义。

关键词：B型利钠肽；N\|端脑利钠肽前体；心力衰竭

ObjectiveTo study the clinical significance of NT\|proBNP in patients with heart failure（HF）.MethodsSerum NT\|proBNP levels were measured in 60 healthy subjects (control group),382 cases of HF(observation group) and 80 cases HF patients at seventh days and fifteenth days after treatment.ResultsSerum NT\|proBNP level in the observation group was significantly higher than that in the control group,the difference was statistically significant (P＜0.01);In the observation group,with the difference of cardiac function classification ,the serum NT\|proBNP level was also different,the difference was statistically significant (P＜0.01).With the increase of cardiac functional classification,the level of serum NT\|proBNP in patients also showed an increasing trend.The blood test results in 80 cases of HF patients at seventh days、fifteenth days showed that with the improvement of cardiac function,NT\|ProBNP levels continued to decline,the difference was statistically significant.ConclusionDetection of serum NT\|ProBNP level has important clinical significance for the diagnosis,the disease condition assessment and the clinical efficacy evaluation in HF patients.Key Words:BNP;NT\|proBNP;Heart failure

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参考文献：

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