中国冶金工业医学杂志

颈动脉粥样硬化改变与血压水平的相关性分析

分类号：R 543

出版年,卷(期):页码：2015,32(6):626-628

摘要：

摘要：目的探讨不同血压水平人群的颈动脉硬化改变分布情况及与血压水平的相关性。方法按血压值＜120/80 mmHg、（120～129）/（80～84）mmHg、(130～139)/（85～89）mmHg)和≥140/90 mmHg分层随机抽取1600例社区居民为观察对象，分别为血压正常组、血压正常高值1期组、血压正常高值2期组和高血压组各400例，均应用彩色多普勒超声检测仪检测双侧颈动脉并测量颈动脉内\|中膜厚度（IMT）及斑块形成情况，了解各组观察对象的颈动脉硬化程度及病灶分布情况。结果（1）颈动脉硬化好发部位依次为颈动脉窦部、颈总动脉、颈内动脉和颈外动脉，硬化病灶分布间比较，差异均有统计学意义（P＜001）。（2）不同血压水平的观察对象其颈动脉硬化检出率不同，正常血压组、血压高值1期组、血压高值2期组和高血压组检出率分别为425%、533%、555%和673%；除血压正常高值1期组与血压正常高值2期组之间的颈动脉硬化检出率无统计学差异外，其余各组间的颈动脉硬化检出率比较差异均有统计学意义(P＜001)。结论颈动脉硬化好发部位主要在颈动脉窦部和颈总动脉；颈动脉粥样硬化程度与血压水平呈明显正相关关系，颈动脉粥样硬化程度随着血压水平的增高而增高；可将IMT增厚和斑块形成作为全身动脉硬化的一个重点筛查指标。

关键词：血压；动脉硬化；颈动脉内\|中膜厚度；斑块形成

Abstract:ObjectiveTo investigate the distribution of carotid atherosclerosis(CAS)and its correlation with the different levels of blood pressure(BP)Methods1600 subjects were selected randomly and divided into 4 groups: normal BP group(BP＜120/80mmHg)，high\|normal BP group 1(BP range 120\|129/80\|84mmHg),high\|normal group 2(BP range 130\|139/85\|89mmHg)and hypertension group(BP≥140/90mmHg),with 400 cases in each groupThe intima media thickness(IMT)and plaque in carotid arteries were observed by Color Doppler ultrasoundThe degree of CAS and the distribution of lesions in each group were analyzedResults①The most common site of CAS were in order of carotid sinus,common carotid artery,internal carotid artery and external carotid artery,and the distribution had statistically difference(P＜001)②The detection rate of CAS in groups were different,respectively 425%,533%、555%,6720% in the normal group,high\|normal BP group 1 and 2 and hypertension groupThere were statistical difference(P＜001)in each groups except between high\|normal BP group 1 and 2ConclusionCAS is most common site in carotid sinus and common carotid artery,the degree of CAS is significantly positively related to BP levels,which will increase with the increase of BP levels;IMT thickness and the formation of plaque can be key screening indexes of systemic atherosclerosisKey Words:Blood pressure;Arteriosclerosis;Carotid arteries intima\|media thickness;Plaque

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参考文献：

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